This picture appears to be consistent with a monoclonal gammopathy of undetermined signiance mgus. Bone marrow biopsy was down to five to ten percent. Obesity and the transformation of monoclonal gammopathy of undetermined significance to multiple myeloma. Agent orange exposure and monoclonal gammopathy of. Observations eleven patients with schnitzler syndrome were treated with oral pefloxacin mesylate 800 mgd. Igm monoclonal gammopathy of undetermined signifi cance mgus to. Sle is another autoimmune disease of unknown etiology that affects primarily women, often in their reproductive. Igm monoclonal gammopathy consists of a broad spectrum of diseases, ranging from apparently benign to malignant conditions. Igm monoclonal gammopathy of undetermined significance and.
Diagnosis of monoclonal gammopathies university of utah. Monoclonal gammopathy of undetermined significance wikipedia. The spectrum of igm monoclonal gammopathy in 430 cases robert a. My igg was little above normal range after five cycles. Igm monoclonal gammopathy is most frequently found in wm and igm mgus.
A diagnosis of multiple myeloma mm is not based on the presence of the monoclonal gammopathy alone. Monoclonal gammopathy of undetermined significance mgus is a clinically asymptomatic premalignant clonal plasma cell or lymphoplasmacytic proliferative disorder. Monoclonal gammopathy of undetermined significance and. Hematologist appt tomorrow hoping for some answers but by the sounds of it it will be more tests, more waiting and sleepless nights. A monoclonal gammopathy is a monoclonal immunoglobulin ig secreted by an abnormally expanded clone of plasma cells in an amount that can be visualized by serum protein electrophoresis spe andor immunofixation of the serum andor urine. Its impossible for me to answer with certainty since i dont know the normal ranges your lab uses. As in multiple myeloma, mgus begins in a type of white blood cells called plasma cells, which produce m. The clinical spectrum of igm monoclonal gammopathy. Igm monoclonal gammopathy of undetermined significance was found in 56% of 430 patients with an igm monoclonal protein seen at mayo clinic. Diagnosis is often done with a lab test called electrophoresis. But in immunoelectrophoresis, kappa and igg suggestive monoclonal gammopathy positive for igg and kappa isotopes. The spectrum of igm monoclonal gammopathy in 430 cases.
Familial clusters of wm show an increased frequency of igm mgus compared with the general population and suggest that the phenotypic spectrum might include polyclonal gammopathy and hypoglobulinemia. This singlecenter study includes 7107 patients with sife confirmed monoclonal gammopathy, with igm type accounting for 5. I dont know if it is acute or chronic without knowing your history. All igg lambda monoclonal protein detected messages. A doctor explains monoclonal gammopathy of undetermined significance mgus, a condition that needs periodic labwork since, in 20 percent of cases, it may develop into cancer multiple myeloma. Monoclonal gammopathies health encyclopedia university. Disease associations with monoclonal gammopathy of.
Which prompted me to check patient portal and i saw ife results stating monoclonal gammopathy iga lamba. Igm monoclonal gammopathy of undetermined significance and smoldering waldenstroms. Igm monoclonal gammopathy of undetermined significance. Monoclonal gammopathy of undetermined significance of igm class igm mgus was diagnosed in 2 mayo clinic patients who were residents of 11 counties in southeastern minnesota from 1960 to 1994. A monoclonal igm paraprotein can be detected in a number of diseases, and a differential diagnosis of igm monoclonal gammopathies is shown in table 1. Unusual manifestations of igm monoclonal gammopathies.
Monoclonal gammopathy of undetermined significance mgus is a condition in which a person has moderately elevated levels of an abnormal immunoglobulin protein called m protein in the blood. Monoclonal gammopathy of undetermined significance mgus is diagnosed in a patient who presents with a monoclonal gammopathy in the absence of histologic evidence, signs, or symptoms of a malignant lymphoproliferative or plasmacytic disorder. International workshop on wm consensus defined igm mgus as a serum igm monoclonal protein of any size without bone marrow involvement by an lpl9. Monoclonal gammopathies are conditions in which abnormal proteins are found in the blood.
What would the lab findings of monoclonal gammopathy be. Monoclonal immunoglobulin definition of monoclonal. Most commonly implicated are lymphoproliferative, myeloproliferative, cardiovascular, and autoimmune disorders. Igmsecreting monoclonal bcell proliferations can cause, in addition to symptoms directly related to the clonal cells, such as bone marrow infiltration, lymphadenopathy and splenomegaly, symptoms due to the monoclonal igm, either by deposition of all or part of its molecule or because of a symptomatic autoantibody activity. The clinical spectrum, underlying disease, and prevalence of igm monoclonal gammopathy have never been reported. What are the tests for monoclonal gammopathy and when.
Monoclonal gammopathy is a fancy way of saying, a disease in which there is a disproportionate amount of a single kind of gamma protein being produced. Mgus resembles multiple myeloma and similar diseases, but the levels of antibodies are. Shimanovsky a, alvarez argote j, murali s, dasanu ca 2016 autoimmune manifestations in patients with multiple myeloma and monoclonal gammopathy of undetermined significance. The most common condition linked with these abnormal proteins is monoclonal gammopathy of undetermined significance mgus. Background schnitzler syndrome is characterized by chronic urticarial rash and monoclonal igm gammopathy and is sometimes associated with periodic fever, arthralgias, and bone pain. Monoclonal gammopathy of undetermined significance and risk of lymphoid and myeloid malignancies. In a longterm followup study of 430 patients in whom a monoclonal igm serum protein had been identified, 242 56% had monoclonal gammopathy of undetermined significance, 71 17% had. Malignant transformation in igm monoclonal gammopathy of. Suffered for years from mixed connective tissue disorder. Igm monoclonal gammopathy of undetermined significance was found in 56% of 430 patients with an igm monoclonal protein seen at mayo clinic between 1956 and 1978.
What is mgus monoclonal gammopathy of undetermined. It is defined by the presence of a serum monoclonal protein m protein at a concentration staphylococcus aureus infection that. In the literature, the distribution of m protein is as follows. We included patients with sife confirmed igm monoclonal gammopathy between january 2008. Mm would also typically include some combination of hypercalcemia high calcium in the blood, kidney failure, anemia, and lesions. In a longterm followup study of 430 patients in whom a monoclonal igm serum protein had been identified, 242 56% had monoclonal gammopathy of. Monoclonal gammopathy of undetermined significance mgus is a plasma cell dyscrasia in which plasma cells or other types of antibodyproducing cells secrete a myeloma protein, i. Novel aspects of wm, igm monoclonal gammopathy and more. Several disorders are associated with the presence of a monoclonal protein in the blood, including multiple myeloma, lymphoma, chronic lymphocytic leukaemia cll and mgus. Mgus is defined by a low level of monoclonal protein less than 30 gl and the absence of anaemia, hypercalcaemia, lytic bone lesions, and renal failure attributable to a plasma cell disorder or lymphoma. Pdf lymphoid neoplasms associated with igm paraprotein a. A single center retrospective study of 377 patients. Monoclonal gammopathies result from the activation of clonal b cellsplasma cells that secrete a particular type of immunoglobulin, called monoclonal protein or m. Monoclonal gammopathy of undetermined significance mgus dx criteria serum m protein 50 years old 5.